• Synthesis of O,O-dialkyl-S-[benzoyl-(benzylidene amino)] dithiophosphorates and their inhibitory effect on acetyl-cholinesterase activity

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    • Keywords


      O,O-Dialkyl dithiophosphoric acid; o/p-benzylidene amino benzoic acid; anti-acetylcholinesterase activity; antihookworm activity

    • Abstract


      A new series of O,O-dialkyl-S-[benzoyl-(o/p-benzylidene amino)] dithiophosphorates have been synthesised and their anti-acetylcholinesterase activity using rat brain homogenate was investigated. The maximum inhibitory activity was exhibited in compound 29 and the minimum in compound12. These compounds were also evaluated for their antihookworm activity againstNippostrongylus brasiliensis in rats andNematospiroids dubius in mice but none of the compounds showed any activity.

    • Author Affiliations


      J S Shukla1 Renu Rastogi1

      1. Department of Chemistry, Lucknow University, Lucknow - 226 007, India
    • Dates

  • Journal of Chemical Sciences | News

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