• Isocoumarins: Part 4. Synthesis of 5,6-dimethoxy, 6,7-dimethoxy, 7,8-dimethoxy, 5,7-dimethoxy, 5,8-dimethoxy-3-methyl-isocoumarins and a new synthesis of (±)-6-methoxy mellein

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    • Keywords


      o-Lithio-N-methylbenzamides; dihydroisocoumarins; isocoumarins

    • Abstract


      o-Lithio 2,3-; 3,4-; 3,5-; 2,5- and 2,4-dimethoxy-N-methyl-benzamides upon condensation with propylene oxide give corresponding dimethoxy-3-methyl-3, 4-dihydroisocoumarins. The method has been used to synthesise (±)-6-methoxy mellein. 3-Methyl-6,7-dimethoxy-3,4-dihydroisocoumarin has been synthesised by an acid catalysed cyclisation reaction. The dihydroisocoumarins have been dehydrogenated to respective isocoumarins.

    • Author Affiliations


      Bhaskar H Bhide1 Dinker I Brahmbhatt1

      1. Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar - 388 120, India
    • Dates

  • Journal of Chemical Sciences | News

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