o-Lithio 2,3-; 3,4-; 3,5-; 2,5- and 2,4-dimethoxy-N-methyl-benzamides upon condensation with propylene oxide give corresponding dimethoxy-3-methyl-3, 4-dihydroisocoumarins. The method has been used to synthesise (±)-6-methoxy mellein. 3-Methyl-6,7-dimethoxy-3,4-dihydroisocoumarin has been synthesised by an acid catalysed cyclisation reaction. The dihydroisocoumarins have been dehydrogenated to respective isocoumarins.
Volume 134, 2022
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