• Structure activity studies on the phenolic substrates in microsomal hydroxylation

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      https://www.ias.ac.in/article/fulltext/jcsc/089/01/0077-0086

    • Keywords

       

      Quantitative structure-activity relationships; Fujita-Ban group contributions; Hansch analysis; phenolic substrates; microsomal hydroxylation

    • Abstract

       

      Quantitative structure-activity relationships have been developed for three series of phenolic substrates viz. phenols, hydroxyindoles and tyramines in microsomal hydroxylation. The Fujita-Ban group contributions of various substituents have been calculated. Mono-, bi-and tri-substituted phenols have been investigated in the light of the linear free energy related model also.

    • Author Affiliations

       

      Harkishan Singh1 2 Vijay Gombar1 2 D V S Jain1 3

      1. Panjab University, Chandigarh - 160 014
      2. Department of Pharmaceutical Sciences, India
      3. Department of Chemistry, India
    • Dates

       
  • Journal of Chemical Sciences | News

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