• A quantitative aspect of charge-transfer phenomenon in the biological activity of hallucinogens, local anesthetics and nicotinic agents

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    • Keywords


      Structure-activity relationship; electronic parameters; drug-receptor interaction; hallucinogens; local anesthetics; nictotinic agents

    • Abstract


      The qualitative electronic structure-activity relationships, that had led some workers to suggest that hallucinogens, local anesthetics, and nicotinic agents exert their biological effect through the formation of charge-transfer complexes with the receptors, are tested statistically. The statistical test is found to support the suggestion along with the observation that in addition to the charge-transfer mechanism, a secondary binding is also involved in the activity of nicotinic agents.

    • Author Affiliations


      S P Gupta1 P Singh1

      1. Department of Chemistry, Birla Institute of Technology and Science, Pilani - 333 031
    • Dates

  • Journal of Chemical Sciences | News

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