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    • Regulation of the Scar/WAVE complex in migrating cells: A summary of our understanding

      SHASHI PRAKASH SINGH

      Review Volume 48 Published: 16 May 2023 Article ID 0016

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      https://www.ias.ac.in/article/fulltext/jbsc/048/0016

    • Keywords

       

      Actin; Arp2/3 complex; cell migration; phosphorylation; Scar/WAVE complex

    • Abstract

       

      Eukaryotic cell migration requires continuous supply of actin polymers at the leading edges to make and extend lamellipodia or pseudopodia. Linear and branched filamentous actin polymers fuel cell migration. Branching of actin polymers in the lamellipodia/pseudopodia is facilitated by the actin-related protein (Arp) 2/3 complex, whose function is essentially controlled by the Scar/WAVE complex. In cells, the Scar/WAVE complex remains inactive, and its activation is a highly regulated and complex process. In response to signalling cues, GTP-bound Rac1 associates with Scar/WAVE and causes activation of the complex. Rac1 is essential but not sufficient for the activation of the Scar/WAVE complex, and it requires multiple regulators, such as protein interactors and modifications (phosphorylation, ubiquitylation, etc.). Although our understanding of the regulation of the Scar/WAVE complex has improved over the last decade, it remains enigmatic. In this review, we have provided an overview of actin polymerization and discussed the importance of various regulators of Scar/WAVE activation.

    • Author Affiliations

       

      SHASHI PRAKASH SINGH1

      1. Wellcome Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK

    • Dates

       
      Published
      16 May 2023

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