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    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/048/0009

    • Keywords

       

      Anti-inflammatory; immune-modulation; immune-suppressive; N-acetyl cysteine; thiol antioxidant

    • Abstract

       

      The present study primarily focuses on the efficacy of Malabaricone C (Mal C) as an anti-inflammatory agent. Mal C inhibited mitogen-induced T-cell proliferation and cytokine secretion. Mal C significantly reduced cellular thiols in lymphocytes. N-acetyl cysteine (NAC) restored cellular thiol levels and abrogated Mal C-mediated inhibition of T-cell proliferation and cytokine secretion. Physical interaction between Mal C and NAC was evinced from HPLC and spectral analysis. Mal C treatment significantly inhibited concanavalin A-induced phosphorylation of ERK/JNK and DNA binding of NF-κB. Administration of Mal C to mice suppressed T-cell proliferation and effector functions ex vivo. Mal C treatment did not alter the homeostatic proliferation of T-cells in vivo but completely abrogated acute graft-versus-host disease (GvHD)-associated morbidity and mortality. Our studies indicate probable use of Mal C for prophylaxis and treatment of immunological disorders caused due to hyper-activation of T-cells.

    • Author Affiliations

       

      RAGHAVENDRA S PATWARDHAN1 KSHAMA KUNDU2 VAITASHI PUROHIT1 BINITA KISLAY KUMAR1 BEENA SINGH3 MAIKHO THOH1 KHUSHBOO UNDAVIA1 HARI N BHILWADE1 SANDIP K NAYAK2 DEEPAK SHARMA1 4 SANTOSH K SANDUR1 4

      1. Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India
      2. Bio-Organic Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India
      3. Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India
      4. Homi Bhabha National Institute, Mumbai 400094, India

    • Dates

       
      Published
      27 March 2023

    • Supplementary Material

       

  • Journal of Biosciences | News

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    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

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