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      https://www.ias.ac.in/article/fulltext/jbsc/046/0054

    • Keywords

       

      Ayurveda; gut microbiome; oral microbiome; prakriti; precision medicine

    • Abstract

       

      Diagnosis and treatment of various diseases in Ayurveda, the Indian system of medicine, relies on ‘prakriti’phenotyping of individuals into predominantly three constitutions, kapha, pitta and vata. Recent studiespropose that microbiome play an integral role in precision medicine. A study of the relationship betweenprakriti – the basis of personalized medicine in Ayurveda and that of gut microbiome, and possible biomarkerof an individual’s health, would vastly improve precision therapy. Towards this, we analyzed bacterialmetagenomes from buccal (oral microbiome) and fecal (gut microbiome) samples of 272 healthy individuals ofvarious predominant prakritis. Major bacterial genera from gut microbiome included Prevotella, Bacteroidesand Dialister while oral microbiome included Streptococcus, Neisseria, Veilonella, Haemophilus, Porphyromonasand Prevotella. Though the core microbiome was shared across all individuals, we found prakritispecific signatures such as preferential presence of Paraprevotella and Christensenellaceae in vata individuals.A comparison of core gut microbiome of each prakriti with a database of ‘healthy’ microbes identifiedmicrobes unique to each prakriti with functional roles similar to the physiological characteristics of variousprakritis as described in Ayurveda. Our findings provide evidence to Ayurvedic interventions based on prakritiphenotyping and possible microbial biomarkers that can stratify the heterogenous population and aid inprecision therapy.

    • Author Affiliations

       

      TIRUMALAPURA VIJAYANNA SHALINI1 APOORVA JNANA2 SITARAM JAIDEEP SRIRANJINI1 ANKIT SINGH TANWAR3 4 ANGELA BRAND3 4 5 THOKUR SREEPATHY MURALI2 KAPAETTU SATYAMOORTHY6 G G GANGADHARAN1

      1. Ramaiah Indic Specialty Ayurveda Restoration Hospital, Bangalore, India
      2. Department of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India
      3. Department of Public Health Genomics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India
      4. United Nations University—Maastricht Economic and Social Research Institute on Innovation and Technology, Maastricht, The Netherlands
      5. Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
      6. Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India
    • Dates

       
  • Journal of Biosciences | News

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