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    • Keywords


      COVID-19; central nervous system; neurotropic mechanism; ACE2 receptor; cytokine storm; coagulation pathway

    • Abstract


      The coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been declared a pandemic. Global research updates confirm that the infected patients manifest a range ofclinical symptoms and sometimes remain entirely asymptomatic, posing a greater threat to the people comingin contact. Despite several case reports coming up every day, our knowledge about the neurotropic mechanismof the SARS-CoV-2, immunological responses, and the mode of disease progression and mechanism of crosstalkbetween the central nervous system (CNS), heart, lungs, and other major organs is not complete. Report ofanosmia, ataxia, dysgeusia, and altered psychological status of the infected COVID-19 patients offers someclue to the possible route of viral entry and multiplication. In this review, we have critically assessed theinvolvement of CNS dysregulation in COVID-19 patients. The probable mechanism of immunologicalresponses, the impairment of the coagulation pathway, the onset of cytokine storm, its interplay with the HPAaxis, and hypoxia are discussed in detail here. Based on the latest research findings and some case reports ofhospitalized COVID-19 patients, it is evident that the CNS involvement in disease progression is alarming.Accurate and timely detection of viral load in CNS is necessary to allow prompt and effective treatmentmodalities.

    • Graphical Abstract


      Possible entry sites of SARS-CoV-2 to the central nervous system of human being and the downstream manifestations.

    • Author Affiliations



      1. Centre for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology (IIEST), Howrah 711 103, India
      2. Department of Neurology, Institute of Postgraduate Medical Education and Research and Bangur Institute of Neurosciences, Kolkata 700 020, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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