• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/046/0040

    • Keywords

       

      Ca2+ release; CACNA1S; Duchenne muscular dystrophy; MRTF-A; phosphorylation modification

    • Abstract

       

      Gene therapy is considered a potential treatment for Duchenne muscular dystrophy (DMD). Researchers havebeen working on this for many years to find effective therapeutic targets. Here, we found that MRTF-A(myocardin-related transcription factor A) could activate the transcription of L-type Ca2+-channel-relatedprotein CACNA1S (calcium voltage-gated channel subunit alpha1 S) by binding to the CarG box in thepromoter of CACNA1S. However, increased phosphorylation and decreased expression of MRTF-A wereobserved, along with the expression of CACNA1S reduced in mdx mice. Further, the decreased expression andincreased phosphorylation of MRTF-A could inhibit the release of Ca2+ via CACNA1S. Therefore, MRTF-Amay be a potential molecular target for the diagnosis and treatment of DMD.

    • Author Affiliations

       

      CHEN LIANG1 YAO XU1 ZHEN PENG1 YING LUO2 TONGCUN ZHANG1

      1. College of Life Science and Health, Wuhan University of Science and Technology, Wuhan 430065, China
      2. College of Biological Science and Technology, Hubei Minzu University, Enshi 445000, China
    • Dates

       
    • Supplementary Material

       
  • Journal of Biosciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.