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      https://www.ias.ac.in/article/fulltext/jbsc/046/0013

    • Keywords

       

      Autoantibodies; cancer; immunophenotypical characterization; paraneoplastic neurological syndromes

    • Abstract

       

      Paraneoplastic neurological syndromes (PNS) are a group of rare and severe immune-mediated disorders thataffect the nervous system in patients with cancer. The best way to diagnose a paraneoplastic neurologicaldisorder is to identify anti-onconeural protein antibodies that are specifically associated with various cancers.The aim of this multicentric study was to clinically and immunologically characterize patients with PNS andstudy their association with cancer. Patients suspected to have PNS were enrolled from various clinical centresand were characterized immunologically. This study population consisted of 112 patients. Onset of PNS wasmainly subacute (76%). PNS patients had various neurological disorders and symptoms. PNS developed beforethe diagnosis of cancer in 28 definite PNS patients and in six suspected PNS patients. The most frequentautoantibodies detected in PNS patients were anti-Hu and anti-Yo. One definite PNS patient with cerebellarsyndrome had anti-Tr antibody and seven patients had atypical antibodies. The literature associates theseantibodies with various neurological disorders and cancers. Our observations confirm the important role ofautoantibodies in PNS and their importance for the early diagnosis of cancer in PNS patients.

    • Author Affiliations

       

      LORENZO LORUSSO1 VINCENZA PRECONE2 IAN K HART3 BRUNO GIOMETTO4 RAFFAELE PEZZANI5 GAELLE K NGONGA6 STEFANO PAOLACCI7 DANIELA FERRARI8 GIOVANNI RICEVUTI9 ERNIE MARSHALL10 MATTEO BERTELLI2 7 11

      1. UOC Neurology and Stroke Unit, ASST Lecco, Merate, LC, Italy
      2. MAGI EUREGIO, Bolzano, Italy
      3. Department of Neurology, The Walton Centre, Liverpool, UK
      4. Department of Neurology, Santa Chiara Hospital, Trento, Italy
      5. Department of Medicine (DIMED), University of Padua, OU Endocrinology, Padua, Italy
      6. Department of Neurology, Hospital Centre Emile Mayrisch, Esch-sur-Alzette, Luxemburg
      7. MAGI’S Lab, Rovereto, TN, Italy
      8. Department of Neurology, Simone Veil Hospital, Eaubonne, France
      9. Laboratory of Cellular Pathophysiology and Clinical Immunology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
      10. The Clatterbridge Cancer Centre, NHS Foundation Trust, Liverpool, UK
      11. EBTNA-LAB, Rovereto, TN, Italy
    • Dates

       
  • Journal of Biosciences | News

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