Obesity is considered a serious global health issue. Patients have been predisposed to comorbidities such asdyslipidemia, cardiovascular diseases, diabetes, cancers, and osteoarthritis. Certain fats in the diet have beenlinked with an increase in obesity, such as saturated and trans-fats. Meanwhile, some dietary fats such asconjugated linoleic acids (CLAs) and medium-chain triglycerides (MCTs) could potentially reduce energyintake. Various mechanisms for reducing weight by CLAs and MCTs, such as increased lipolysis, improvedintestinal microbiota, up-regulating peroxisome proliferator-activated receptors (PPARs), increased theexpression of uncoupling protein of respiratory chain-1 (UCP-1), and affected satiety hormones are included.These bioactive compounds, CLAs and MCTs, should be used in moderate concentrations to prevent harmfuleffects such as insulin resistance for CLAs and hypercholesterolemia for MCTs. However, several studies haveproposed CLAs or MCTs as adjuvants to the protocol used to minimize bodyweight. Our objective is tosummarize the different causes of obesity and to discuss the effects of CLAs or MCTs on body weight and fatdeposition in obese animals or humans.
Volume 46, 2021
Continuous Article Publishing mode
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