• Pattern of genomic variation in SARS-CoV-2 (COVID-19) suggests restricted nonrandom changes: Analysis using Shewhart control charts

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    • Keywords


      SARS-CoV-2; SARS-Cov-1; MERS; Shewhart control chart; hotspots

    • Abstract


      SARS-CoV-2 is a member of the Coronavirus family which recently originated from the Wuhan province ofChina and spread very rapidly through the world infecting more than 4 million people. In the past, otherCoronaviruses have also been found to cause human infection, but not as widespread as COVID-19. SinceCoronavirus sequences constantly change due to mutation and recombination, it is important to understand thepattern of changes and likely path the virus can take in the future. In this study, we have used the Shewhartcontrol chart to identify and analyze hypervariable (hotspots) and hypovariable (coldspots) regions of the virus.Our analysis shows that SARS-CoV-2 has changed in a few regions of the genome. Analysis of SARS-CoV-1and MERS sequences suggests that over time, mutations start accumulating in different regions and most likelySARS-CoV-2 may also follow a similar path. The results suggest a possible emergence of modified virusesover some time.

    • Author Affiliations



      1. School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India
      2. Department of Internal Medicine, Cardiology, University of Michigan, Ann Arbor, MI, USA
      3. Department of Biology, Ashoka University, Sonepat, Haryana, India
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