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      https://www.ias.ac.in/article/fulltext/jbsc/046/0005

    • Keywords

       

      Aspergilli; fusion proteins; heterologous expression; secretion pathways; unfolded protein response

    • Abstract

       

      In the search for optimal platforms for protein expression and secretion, filamentous fungi in principle providesome of the best microbial cell factories. They are inherently endowed with the ability to secrete proteins.Fungi belonging to Aspergillus and Trichoderma species are well-studied for industrial production of proteinsand enzymes. Our understanding of these organisms at the level of transcription, translation, post-translationalprocessing and the secretory pathways has improved significantly in recent years. Despite this, the ability ofthese fungal secretion platforms has not yet been able to match their intrinsic secretion capacity to produceforeign proteins. Details of the molecular mechanisms of the secretory pathways in filamentous fungi areemerging. This knowledge can be gainfully employed to enhance protein production in filamentous fungi,particularly in the secretion of heterologous proteins of value.

    • Author Affiliations

       

      ANUP A SAKEKAR1 SANTOSHKUMAR R GAIKWAD1 NARAYAN S PUNEKAR1

      1. Metabolism and Enzymology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400 076, India
    • Dates

       
  • Journal of Biosciences | News

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