An unprecedented worldwide spread of the SARS-CoV-2 has imposed severe challenges on healthcarefacilities and medical infrastructure. The global research community faces urgent calls for the development ofrapid diagnostic tools, effective treatment protocols, and most importantly, vaccines against the pathogen.Pooling together expertise across broad domains to innovate effective solutions is the need of the hour. Withthese requirements in mind, in this review, we provide detailed critical accounts on the leading efforts atdeveloping diagnostics tools, therapeutic agents, and vaccine candidates. Importantly, we furnish the readerwith a multidisciplinary perspective on how conventional methods like serology and RT-PCR, as well ascutting-edge technologies like CRISPR/Cas and artificial intelligence/machine learning, are being employed toinform and guide such investigations. We expect this narrative to serve a broad audience of both active andaspiring researchers in the field of biomedical sciences and engineering and help inspire radical newapproaches towards effective detection, treatment, and prevention of this global pandemic.