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    • Keywords


      Breast cancer; epithelial-mesenchymal transition; leukemia inhibitory factor; metastasis; proliferation

    • Abstract


      Breast cancer is the second leading cause of cancer-related death among females, worldwide. The cytokines areproteins that have a significant role in the development of tumor growth. Leukemia inhibitory factor (LIF) ofthe interleukin-6 cytokines superfamily plays a significant role, by the modulation of many signaling pathways.This study summarizes some current works in breast cancer, in which LIF intervention is being discussed. LIFpromotes tumorigenesis, invasion, migration of breast cancer cells in vitro, metastasis of breast cancer in vivo,epithelial-mesenchymal transition, and mediates pro-invasive activation of stromal fibroblast. LIF contributesto inducing growth, tumorigenesis, and metastasis of breast cancer and is a significant biomarker for breasttumors and can be a therapeutic target for clinical intervention.

    • Author Affiliations



      1. Department of Cell and Molecular Biology, School of Biology, Kish International Campus, University of Tehran, Kish, Iran
      2. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Medical Technologies, Isfahan University of Medical Sciences, Isfahan, Iran
      3. Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
      4. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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