• A cross-eyed geneticist’s view VI. Segregation distortion in Drosophila melanogaster: Recent progress in solving ‘an esoteric puzzle’

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    • Keywords


      Nucleus-cytoplasm transactions; Ran gradient; transmission ratio distortion

    • Abstract


      Segregation distortion refers to an unusual genetic phenomenon in diploid organisms by which the two alleles at a locus in a parent are not recovered in the classical 1:1 Mendelian ratio in its offspring. The Drosophila melanogaster neogene Sd was created by a duplication breakpoint on the left arm of chromosome 2 (2L), and encodes a truncated RanGAP protein with normal GTPase activity but which mis-localizes to the nucleus and disrupts Ran gradients. Male flies carrying Sd exhibit segregation distortion for the Rsp locus on the right arm of chromosome 2 (2R). Specifically, spermatids inheriting chromosome 2 with the Sd+ Rsps(s) genotype, in heterozygous males of genotype Sd Rspi /Sd+ Rsps(s), fail to develop properly so that the majority of progeny (approaching 100%) carry just the Sd Rspi chromosome. One recent paper reported novel RNAi-expressing transgenes with Sd-mimicking properties; and another reported localization of an X-linked suppressor which restores Mendelian transmission. This article highlights how Drosophila genetics resources made this possible, and the significance of these findings to nucleus-cytoplasm transactions of interest to the wider cell biology community.

    • Author Affiliations



      1. Centre for DNA Fingerprinting and Diagnostics, Uppal, Hyderabad 500 039, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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