• Development of local vancomycin delivery system from fibrin gel to prevent Staphylococcus aureus biofilms graft infection

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      https://www.ias.ac.in/article/fulltext/jbsc/045/0124

    • Keywords

       

      Antibiotic; biofilm; drug delivery system; fibrin gel; graft infection

    • Abstract

       

      Prosthetic vascular graft infection is one of the most severe vascular surgery complications. Fibrin gel (FG) hasmany useful characteristics as biocompatibility, biodegradation, adhesion, and haemostasis to develop the localantibiotic delivery system. In this study, human plasma was collected from peripheral blood that was used tocreate fibrin gel by supplement ion Ca2+. Antibiotic-containing fibrin gel was then evaluated in some characteristicssuch as surface structure, biodegradation, antibiotic delivery, cytotoxicity, and bacterial biofilmprevention in vitro and in vivo. The results showed that fibrin gel was excellent material for the extendeddelivery of antibiotics. Most importantly, antibiotic-containing fibrin gel was not toxic for human fibroblastcells in vitro and inhibited bacterial biofilm growth in vitro and in vivo. This research is the first step indeveloping an antibiotic delivery system for effective graft infection treatments.

    • Author Affiliations

       

      VU NGUYEN DOAN1 2 3 TUNG THANH TRUONG2 3 HA LE BAO TRAN1 2 3

      1. Laboratory of Tissue Engineering and Biomedical Materials, University of Science, Vietnam National University, Ho Chi Minh City 700000, Vietnam
      2. Department of Physiology and Animal Biotechnology, Faculty of Biology and Biotechnology, University of Science, Vietnam National University, Ho Chi Minh City 700000, Vietnam
      3. Vietnam National University, Ho Chi Minh City 700000, Vietnam
    • Dates

       
  • Journal of Biosciences | News

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