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Coronavirus; counter-defense; RNA interference; RNAi suppressor; SARS-CoV; v-siRNA

The two biological evidences to endorse the antiviral activity of RNA interference (RNAi) are biogenesis ofviral-siRNA (v-siRNA) by the host and encoding of RNAi-suppressor protein by viral genome. It has beenrecently established that mammals and mammalian cell lines mount antiviral RNAi to defend themselvesagainst the invading viruses. The large part of viral pathogenicity is also due to the RNAi suppressor proteins.In this context it is only natural to ask what kinds of RNAi suppressors are encoded by the Severe AcuteRespiratory Syndrome Coronavirus 2 (SARS-CoV-2), the central character of the present pandemic. Thefollowing mini review addresses this question.

SUMONA KARJEE¹ SUNIL KUMAR MUKHERJEE²

1. Molecular Biology Department, Prantae Solutions Private Limited, Bhubaneswar 751 024, India
2. Division of Plant Pathology, Indian Agricultural Research Institute, New Delhi 110 012, India

Published

16 July 2020