• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/045/0099

    • Keywords

       

      Coronavirus; counter-defense; RNA interference; RNAi suppressor; SARS-CoV; v-siRNA

    • Abstract

       

      The two biological evidences to endorse the antiviral activity of RNA interference (RNAi) are biogenesis ofviral-siRNA (v-siRNA) by the host and encoding of RNAi-suppressor protein by viral genome. It has beenrecently established that mammals and mammalian cell lines mount antiviral RNAi to defend themselvesagainst the invading viruses. The large part of viral pathogenicity is also due to the RNAi suppressor proteins.In this context it is only natural to ask what kinds of RNAi suppressors are encoded by the Severe AcuteRespiratory Syndrome Coronavirus 2 (SARS-CoV-2), the central character of the present pandemic. Thefollowing mini review addresses this question.

    • Author Affiliations

       

      SUMONA KARJEE1 SUNIL KUMAR MUKHERJEE2

      1. Molecular Biology Department, Prantae Solutions Private Limited, Bhubaneswar 751 024, India
      2. Division of Plant Pathology, Indian Agricultural Research Institute, New Delhi 110 012, India
    • Dates

       
  • Journal of Biosciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.