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      https://www.ias.ac.in/article/fulltext/jbsc/045/0098

    • Keywords

       

      Bone marrow mesenchymal stem cells; cytokine; immune disorders; immunomodulation; immunosuppression

    • Abstract

       

      Bone marrow mesenchymal stem cells (BM-MSCs) are multipotent progenitor cells of mesodermal originpossessing multilineage differentiation potential and ease of expansion in vitro. Over the years, these cells havegained attention owing to their potential in cell-based therapies in treating various diseases. In particular, thewide spectrum of immunoregulatory/immunomodulatory role of MSCs in various clinical conditions hasgained immense attention. The immunomodulatory properties of BM-MSCs are mediated by either cell–cellcontact (interactions with various immune cells in a context-dependent manner), paracrine mode of action orextracellular vesicles, making them a potential option as immunosuppressants/immunomodulators in treatingvarious clinical conditions. A plethora of studies have demonstrated that MSCs do so by exhibiting a profoundeffect on various immune cells for example they can inhibit the proliferation of T cells, B cells, and naturalkiller cells; modulate the activities of dendritic cells and induce regulatory T cells both in vitro and in vivo. Inthis review we aim at briefly elucidating the characteristics of BM-MSCs, specifically addressing the currentunderstanding on the hypoimmunogeneticity and immunomodulatory properties of the same with specificreference to their interactions with B cells, T cells, Dendritic cells and natural killer cells. We also aim atreviewing the secretory profile and their role in some clinical conditions that have shown promising outcomes.

    • Author Affiliations

       

      APARNA MOHANTY1 NARESH POLISETTI2 GEETA K VEMUGANTI1

      1. School of Medical Sciences, University of Hyderabad, Hyderabad, India
      2. Klinik fu¨ r Augenheilkunde, Universita¨tsklinikum Freiburg, Killianstr. 5, 79106 Freiburg, Germany
    • Dates

       
  • Journal of Biosciences | News

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