• Dynamics of sequestering the limiting p300/CBP, viral cis-regulatory elements, and disease

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    • Keywords


      cAMP; CBP; E1A protein; enhancer; HPV18; limiting; microcompetition; p300; sequester

    • Abstract


      Many studies showed that the p300/CBP coactivator is limiting. Here we review three studies that showed howtranscription complexes formed on viral cis-regulator elements compete with cellular transcription complexesby sequestrating the p300/CBP coactivator. According to the microcompetition model, this sequestering cancause disease. We use the microcompetition model to explain how a specific type of sequestering, caused by alatent virus that has an active cis-regulatory element in its promoter/enhancer that binds the transcriptioncomplex p300/CBP.GABP can cause diseases such as cancer, atherosclerosis, diabetes, and certain autoimmunediseases.

    • Author Affiliations



      1. The Center for the Biology of Chronic Disease (CBCD), 616 Corporate Way, Suite 2-3665, Valley Cottage, NY 10989, USA
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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