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    • Keywords


      Functional connectivity; memory; temporal lobe epilepsy (TLE); surgery; voxel-based morphometry (VBM)

    • Abstract


      Persons with drug refractory TLE have the option of being managed by surgery. They may develop memoryimpairment with specific etiology of mesial temporal sclerosis and anterior temporal lobe resection (ATLR).The study evaluated the semantic verbal memory outcomes in pre- and post-surgery temporal lobe epilepsy(TLE) patients using functional MRI and voxel morphometric methods. Twenty consecutive persons withdrug-resistant epilepsy (DRE) and 20 healthy controls were recruited after obtaining the institute ethicsapproval. The fMRI scans were performed on a 1.5 T MR Scanner using standardized semantic verbal memorytasks using a native Hindi paradigm, before and after an anterior temporal lobectomy (in cases). A task-basedfunctional connectivity (FC) was estimated using a conn toolbox. Data analysis was carried out using thestatistical parametric imaging (SPM12) and CAT12 toolbox. Post-surgery TLE group showed increased robustFC in the right middle and posterior temporal regions as compared to pre-surgery session. A significantreduction in grey matter volume was observed in the left temporal lobe post-operatively as compared to presurgeryand healthy control groups. In the post-surgery TLE group, neuropsychological scores were reduced inspecific PGI domains such as visuospatial, working memory, and executive functioning. Our results may helpin understanding of memory reorganization in TLE post-operatively.

    • Author Affiliations



      1. Department of Nuclear Magnetic Resonance, All India Institute of Medical Sciences, New Delhi, India
      2. Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
      3. Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
      4. Department of Neuropsychology, All India Institute of Medical Sciences, New Delhi, India
    • Dates

  • Journal of Biosciences | News

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