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      https://www.ias.ac.in/article/fulltext/jbsc/045/0072

    • Keywords

       

      AZT; breast cancer; EMT; hTERT; TRAP assay

    • Abstract

       

      Telomerase is a specialized enzyme which maintains telomere length at the extreme end of the chromosome.Over 90% of all cases of cancer show high expression of telomerase while in normal cells, its expression isextremely low or undetectable. Detection of telomerase activity in a wide range of breast cancer makestelomerase an interesting target for diagnosis and therapy. In this review, we have aimed to describe telomeraseas a therapeutic and accurate diagnostic target in breast cancer. Telomerase performs many extracurricularactivities apart from maintaining telomere length; here, we have also tried to address its role in epithelialmesenchymaltransition (EMT) of breast cancer progression.

    • Author Affiliations

       

      RISHI KUMAR JAISWAL1 PRAMOD KUMAR YADAVA1 2

      1. Applied Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
      2. Present Address: Department of Biological Sciences, Indian Institute of Science Education and Research, Berhampur, Odisha 760 010, India
    • Dates

       
  • Journal of Biosciences | News

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