Global efforts on vaccines for COVID-19: Since, sooner or later, we all will catch the coronavirus
COVID-19 is an emerging infectious disease that has turned into a pandemic. It spreads through droplet transmissionof the new coronavirus SARS-CoV-2. It is an RNA virus displaying a spike protein as the major surfaceprotein with significant sequence similarity to SARS-CoV which causes severe acute respiratory syndrome. Thereceptor binding domain of the spike protein interacts with the human angiotensin converting enzyme 2 and isconsidered as the antigenic determinant for stimulating an immune response. While multiple candidate vaccines arecurrently under different stages of development, there are no known therapeutic interventions at the moment. Thisreview describes the key genetic features that are being considered for generating vaccine candidates by employinginnovative technologies. It also highlights the global efforts being undertaken to deliver vaccines for COVID-19through unprecedented international cooperation and future challenges post development.
Volume 46, 2020
Continuous Article Publishing mode
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