• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/045/0055

    • Keywords

       

      Fourier transform infrared spectroscopy; & alpha; -helical structure; post-traumatic epilepsy

    • Abstract

       

      Tissue analysis by Fourier transform infrared (FTIR) imaging can determine the biodistribution of molecules,without pre-analytical modification. We aimed to study the infrared spectroscopic changes of α-helical proteinsat post-traumatic epileptic (PTE) foci by FTIR. FITR mapping was applied to detect α-helical proteins in ratbrain tissue samples with post-traumatic epilepsy. Histological examination of brain sections showed that therat model of PTE was successfully established. At the PTE foci, high α-helical absorption regions wereevident, where the color difference and absorption were significantly different from those in the low-absorptionregions. This provided a distinctive and characteristic pattern at the site of lesions. The use of FTIR imagingmeans that it is possible to measure the molecular structural changes resulting from PTE pathologies in tissues,providing a novel adjunct to conventional pathological diagnostic techniques.

    • Author Affiliations

       

      SIYANG XIANG1 2 DONG ZHAO1 2 HONGXIA HAO1 XU WANG1 LING LI3 TIANTONG YANG1

      1. Center of Cooperative Innovation for Judicial Civilization, Beijing 100088, China
      2. China University of Political Science and Law, Key Laboratory of Evidence Science, Ministry of Education, Beijing 100088, China
      3. Office of the Chief Medical Examiner, State of Maryland, Baltimore, USA
    • Dates

       
  • Journal of Biosciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2017-2019 Indian Academy of Sciences, Bengaluru.