• The CBX family of proteins in transcriptional repression and memory

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    • Keywords


      CBX; chromatin; epigenetic memory; nucleosome compaction; phase separation; Polycomb Repressive Complex

    • Abstract


      For mammals to develop properly, master regulatory genes must be repressed appropriately in a heritablemanner. This review concerns the Polycomb Repressive Complex 1 (PRC1) family and the relationshipbetween the establishment of repression and memory of the repressed state. The primary focus is on the CBXfamily of proteins in PRC1 complexes and their role in both chromatin compaction and phase separation.These two activities are linked and might contribute to both repression and memory.

    • Author Affiliations



      1. Department of Molecular Biology and MGH Research Institute, Massachusetts General Hospital, Boston, MA, USA
      2. Department of Genetics, Harvard Medical School, Boston, MA, USA
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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