• Regulation of epigenetic state by non-histone chromatin proteins and transcription factors: Implications in disease

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    • Keywords


      Cancer; chromatin organization; neurodegenerative disorders; neurogenesis; P300/CBP; posttranslational modifications

    • Abstract


      Besides the fundamental components of the chromatin, DNA and octameric histone, the non-histone chromatinproteins and non-coding RNA play a critical role in the organization of functional chromatin domains. Thenon-histone chromatin proteins therefore regulate the transcriptional outcome in both physiological andpathophysiological state as well. They also help to maintain the epigenetic state of the genome indirectly.Several transcription factors and histone interacting factors also contribute in the maintenance of the epigeneticstates, especially acetylation by the induction of autoacetylation ability of p300/CBP. Alterations of KATactivity have been found to be causally related to disease manifestation, and thus could be potential therapeutictarget.

    • Author Affiliations



      1. Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru 560 064, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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