• Phase-separation in chromatin organization

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    • Keywords


      Histone; nucleosome; heterochromatin; phase-separation; auto-inhibition

    • Abstract


      The organization of chromatin into different types of compact versus open states provides a means to fine tune generegulation. Recent studies have suggested a role for phase-separation in chromatin compaction, raising new possibilitiesfor regulating chromatin compartments. This perspective discusses some specific molecular mechanismsthat could leverage such phase-separation processes to control the functions and organization of chromatin.

    • Author Affiliations



      1. Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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