• Phase-separation in chromatin organization

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      https://www.ias.ac.in/article/fulltext/jbsc/045/0005

    • Keywords

       

      Histone; nucleosome; heterochromatin; phase-separation; auto-inhibition

    • Abstract

       

      The organization of chromatin into different types of compact versus open states provides a means to fine tune generegulation. Recent studies have suggested a role for phase-separation in chromatin compaction, raising new possibilitiesfor regulating chromatin compartments. This perspective discusses some specific molecular mechanismsthat could leverage such phase-separation processes to control the functions and organization of chromatin.

    • Author Affiliations

       

      GEETA J NARLIKAR1

      1. Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
    • Dates

       
  • Journal of Biosciences | News

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