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      https://www.ias.ac.in/article/fulltext/jbsc/044/04/0106

    • Keywords

       

      Age reprogramming; Epigenetic rejuvenation; iPS cells; reprogramming factors; Epigenetic clock; eAge

    • Abstract

       

      It has been proposed that age reprogramming enables old cells to be rejuvenated without passage through an embryonicstage (Singh and Zacouto in J. Biosci. 35 315–319, 2010). As such, age reprogramming stands apart from the inducedpluripotent stem (iPS) and nuclear transfer-embryonic stem (NT-ES) cell therapies where histo-compatible cells are producedonly after passage through an embryonic stage. It avoids many of the disadvantages associated with iPS and NT-EScell therapies. Experimental evidence in support of age reprogramming is burgeoning. Here, we discuss possible newapproaches to enhance age reprogramming, which will have considerable benefits for regenerative therapies.

    • Author Affiliations

       

      PRIM B SINGH1 2 3 PETR P LAKTIONOV2 ANDREW G NEWMAN3

      1. Nazarbayev University School of Medicine, Z05K4F4 Astana, Kazakhstan
      2. Epigenetics Laboratory, Department of Natural Sciences, Novosibirsk State University, Novosibirsk, Russian Federation 630090
      3. Institute of Cell and Neurobiology, Charite´ – Universita¨tsmedizin Berlin, Corporate member of Freie Universita¨t Berlin, Humboldt-Universita¨t zu Berlin, and Berlin Institute of Health, Berlin, Germany
    • Dates

       
  • Journal of Biosciences | News

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