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      https://www.ias.ac.in/article/fulltext/jbsc/043/05/1069-1075

    • Keywords

       

      Downstream effects; gene expression; regulatory SNPs (rSNPs); transcriptome

    • Abstract

       

      Currently, it is generally accepted that the cis-acting effects of noncoding variants on gene expression are a major factor forphenotypic variation in complex traits and disease susceptibility. Meanwhile, the protein products of many target genes forthe identified cis-regulatory variants (rSNPs) are regulatory molecules themselves (transcription factors, effectors, componentsof signal transduction pathways, etc.), which implies dramatic downstream effects of these variations on complexgene networks. Here, we brief the results of recent most comprehensive studies on the role of rSNPs in transcriptionalregulation across the genome.

    • Author Affiliations

       

      VASILY M MERKULOV1 ELENA YU LEBERFARB1 TATIANA I MERKULOVA1 2

      1. Laboratory of Gene Expression Regulation, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
      2. Novosibirsk State University, Novosibirsk, Russia
    • Dates

       
  • Journal of Biosciences | News

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