Currently, it is generally accepted that the cis-acting effects of noncoding variants on gene expression are a major factor forphenotypic variation in complex traits and disease susceptibility. Meanwhile, the protein products of many target genes forthe identified cis-regulatory variants (rSNPs) are regulatory molecules themselves (transcription factors, effectors, componentsof signal transduction pathways, etc.), which implies dramatic downstream effects of these variations on complexgene networks. Here, we brief the results of recent most comprehensive studies on the role of rSNPs in transcriptionalregulation across the genome.
Volume 45, 2020
Continuous Article Publishing mode
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