Herein, an antibiotic-loaded electrospun scaffold with improved drug delivery via acoustic stimulation has been developed.Ultrasound stimulus with an intensity of 15 W/cm2, duty-cycle of 50% and duration of 10 min was repeatedly applied tociprofloxacin loaded alginate fibers. Ultrasonication with the aforesaid conditions increased drug release from scaffoldprobably due to disturbance of ionic crosslinks of alginate network. Scaffolds exposed to acoustic stimulus revealed higherantibacterial activity compared to those with no stimulus. Interestingly, antibiotic release radically increased andantibacterial function improved as ultrasound perturbed scaffold framework, but scaffold integrity was regained once theultrasound probe was retracted.
Volume 45, 2020
Continuous Article Publishing mode
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