• On-demand release of ciprofloxacin from a smart nanofiber depot with acoustic stimulus

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    • Keywords


      Alginate; antibiotic; electrospinning; fiber; ultrasound

    • Abstract


      Herein, an antibiotic-loaded electrospun scaffold with improved drug delivery via acoustic stimulation has been developed.Ultrasound stimulus with an intensity of 15 W/cm2, duty-cycle of 50% and duration of 10 min was repeatedly applied tociprofloxacin loaded alginate fibers. Ultrasonication with the aforesaid conditions increased drug release from scaffoldprobably due to disturbance of ionic crosslinks of alginate network. Scaffolds exposed to acoustic stimulus revealed higherantibacterial activity compared to those with no stimulus. Interestingly, antibiotic release radically increased andantibacterial function improved as ultrasound perturbed scaffold framework, but scaffold integrity was regained once theultrasound probe was retracted.

    • Author Affiliations



      1. Biomedical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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