• Primary study on the hypoglycemic mechanism of 5rolGLP-HV in STZ-induced type 2 diabetes mellitus mice

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    • Keywords

       

      5rolGLP-HV; hypoglycemic mechanisms; optimal dose; T2DM

    • Abstract

       

      5rolGLP-HV is a promising dual-function peptide for the treatment of diabetes and thrombosis simultaneously. Forinvestigating the therapeutic mechanism of 5rolGLP-HV for type 2 diabetes mellitus (T2DM), STZ-induced diabetic micewere established and treated with 5rolGLP-HV. The results showed that daily water and food intake, blood glucose, serumand pancreatic insulin levels significantly decreased after 5rolGLP-HV treatment with various oral concentrations, and 16mg/kg was the optimal dose for controlling diabetes. 5rolGLP-HV treatment decreased the MDA levels and the T-SODactivity in serum and pancreatic of diabetic mice (but not up to significant difference), and significantly increased theexpression of signal pathways related genes of rolGLP-1, also the density of insulin expression and the numbers ofapoptosis cells in islets of diabetic mice were significantly decreased in comparison to the negative diabetic mice. Theseeffects above may be clarified the hypoglycemic mechanisms of 5rolGLP-HV, and 5rolGLP-HV may be as a potential drugfor diabetes in future.

    • Author Affiliations

       

      YANAN WANG1 MINGGANG LI2 ZAIZHONG NI1

      1. Lianyungang Maternal and Children’s Health Hospital, Lianyungang 222001, Jiangsu, China
      2. Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, Tianjin 300071, China
    • Dates

       
  • Journal of Biosciences | News

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