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      https://www.ias.ac.in/article/fulltext/jbsc/043/05/0887-0895

    • Keywords

       

      Cardiac hypertrophy; cell death; hyperthyroidism; inflammation; PGC1-& alpha;

    • Abstract

       

      Hyperthyroidism can lead to the activation of proteins which are associated with inflammation, apoptosis, hypertrophy, and heart failure. This study aimed to explore the inflammatory and apoptotic proteins involved in the hyperthyroidism-inducedcardiac hypertrophy establishment. Male Wistar rats were divided into control and hyperthyroid (12 mg/L L-thyroxine, indrinking water for 28 days) groups. The expression of inflammatory and apoptotic signaling proteins was quantified in the left ventricle by Western blot. Hyperthyroidism was confirmed by evaluation of T3 and T4 levels, as well as cardiac hypertrophy development. There was no change in the expression of HSP70, HIF1-α, TNF-α, MyD88, p-NFκB, NFκB,p-p38, and p38. Reduced expression of p53 and PGC1-α was associated with increased TLR4 and decreased IL-10expression. Decreased Bcl-2 expression and increased Bax/Bcl-2 ratio were also observed. The results suggest that reducedPGC1-a and IL-10, and elevated TLR4 proteins expression could be involved with the diminished mitochondrial biogenesisand anti-inflammatory response, as well as cell death signaling, in the establishment of hyperthyroidism-inducedmaladaptive cardiac hypertrophy.

    • Author Affiliations

       

      RAYANE BRINCK TEIXEIRA1 TATIANE EVELYN BARBOZA2 CARLA CRISTINA DE ARAU´ JO1 RAFAELA SIQUEIRA1 ALEXANDRE LUZ DE CASTRO1 JE´ SSICA HELLEN POLETTO BONETTO1 BRUNA GAZZI DE LIMA-SEOLIN1 CRISTINA CAMPOS CARRARO1 ADRIANE BELLO´ -KLEIN1 PAWAN K SINGAL3 ALEX SANDER DA ROSA ARAUJO1

      1. Laborato´ rio de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto de Cieˆncias Ba´sicas da Sau´de, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
      2. Laborato´rio de Disfunc¸o˜es Cardiovasculares, Departamento de Anatomia, Universidade de Sa˜o Paulo, Sa˜o Paulo, Brazil
      3. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, University of Manitoba, Winnipeg, MB, Canada
    • Dates

       
  • Journal of Biosciences | News

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