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    • Genome 3D-architecture: Its plasticity in relation to function

      KUNDAN SENGUPTA

      Mini-Review Volume 43 Issue 2 June 2018 pp 417-419

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/043/02/0417-0419

    • Keywords

       

      Chromatin; CTCF; euchromatin; heterochromatin; nucleolus; nucleoporins; nucleus; phase separation

    • Abstract

       

      The genome of higher eukaryotes is non-randomly organized in the interphase nucleus. However, notwithstanding theabsence of membrane bound sub-compartments, the nucleus coordinates a number of functions largely by organizingchromatin in a non-random but dynamic manner. The plasticity of chromatin structure and function relies on epigeneticmodifications as well as its association with nuclear landmarks such as the nuclear envelope, nuclear lamina, nuclear porecomplex and nuclear bodies such as the nucleolus among others. In the absence of membrane-bound compartments, cellsand the nucleus, in particular, employ phase-separation, which unmixes phases that constrain biochemical reactions incomplex non-membranous sub-compartments such as the nucleolus or even the heterochromatin. This review attempts toprovide a glimpse into the microcosm of phase-separated nuclear sub-compartments, that regulate nuclear structure–function relationships.

    • Author Affiliations

       

      KUNDAN SENGUPTA1

      1. Indian Institute of Science Education and Research, Pune, India

    • Dates

       
      Published
      1 June 2018

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    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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