• Triacylglycerol: nourishing molecule in endurance of Mycobacterium tuberculosis

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      https://www.ias.ac.in/article/fulltext/jbsc/043/01/0149-0154

    • Keywords

       

      Foamy macrophages; LipY; Mycobacterium tuberculosis; TAG; Tgs

    • Abstract

       

      The ability of Mycobacterium tuberculosis (M. tuberculosis) to accumulate lipid-rich molecules as an energy sourceobtained from host cell debris remains interesting. Additionally, the potential of M. tuberculosis to survive under differentstress conditions leading to its dormant state in pathogenesis remains elusive. The exact mechanism by which these lipidbodies generated in M. tuberculosis infection and utilized by bacilli inside infected macrophage for its survival is still notunderstood. In this, during bacillary infection, many metabolic pathways are involved that influence the survival of M.tuberculosis for their own support. However, the exact energy source derived from infecting host cells remain elusive.Therefore, this study highlights several alternative energy sources in the form of triacylglycerol (TAG) and fatty acids, i.e.oleic acids accumulation, which are essential in dormancy-like state under M. tuberculosis infection. The prominent stage intuberculosis (TB) infection is re-establishment of M. tuberculosis under stress conditions and deployment of a confinedstrategy to utilize these biomolecules for its persistence survival. So, growing in our understanding of these pathways willhelp us in accelerating therapies, which could reduce TB prevalence world widely.

    • Author Affiliations

       

      PRATAP C MALI1 LAXMAN S MEENA2

      1. Department of Zoology, University of Rajasthan, Jaipur 322 219, India
      2. CSIR–Institute of Genomics and Integrative Biology, New Delhi 110 007, India
    • Dates

       
  • Journal of Biosciences | News

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      Posted on July 25, 2019

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