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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/042/03/0491-0499

    • Keywords

       

      Cervical cancer; hypoxia; Rab11; Rac1; αvβ3/FAK/PI3K

    • Abstract

       

      Hypoxia plays a key role in tumour cell survival, invasion, and metastasis. An increasing number of studies have attemptedto characterize the tumour response to hypoxia and to identify predictive markers of disease. Here we show that hypoxiaincreases tumour cell invasion and migration by the modulation of Rab11, an important molecule for vesicular trafficking.In our study, we found that Rab11, together with the activation of Rac1, could stimulate invasion and migration of cervicalcancer cell lines HeLa/SiHa in hypoxia. Activation of Rac1 activity by hypoxia seems to be central to carcinoma invasion.We also found that these effects could be related to the integrin αvβ3. In addition, we studied the molecular pathway for thisprocess. Our results showed that in cervical cancer cell lines HeLa/SiHa, Rac1 activation in hypoxia could stimulateinvasion and migration, and this process was mediated by integrin αvβ3-mediated FAK and PI3K phosphorylation.Furthermore, hypoxia induced a dramatic increase in αvβ3 integrin surface expression, and this increase is dependent onRab11. In conclusion, our study might provide a new mechanism for the effect of hypoxia on stimulating cervicalcarcinoma invasion.

    • Author Affiliations

       

      HAO XU1 YUAN YUAN2 WENQIAN WU3 MIN ZHOU4 QIAN JIANG1 LINJUN NIU5 JIAYIN JI1 NIANLI LIU6 LONGZHEN ZHANG1 XIA WANG1

      1. Department of Radiotherapy, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
      2. Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
      3. Department of Immunology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
      4. Intensive Care Unit, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
      5. Department of Interventional Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
      6. Tumor Biological Therapy Institute, Xuzhou Medical University, Xuzhou, China
    • Dates

       
  • Journal of Biosciences | News

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