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      https://www.ias.ac.in/article/fulltext/jbsc/042/01/0161-0173

    • Keywords

       

      Cancer immunotherapy; dendritic cell; tumour immunity

    • Abstract

       

      The interplay between host immunity and tumour cells has opened the possibility of targeting tumour cells bymodulation of the human immune system. Cancer immunotherapy involves the treatment of a tumour by utilizing therecombinant human immune system components to target the pro-tumour microenvironment or by revitalizing theimmune system with the ability to kill tumour cells by priming the immune cells with tumour antigens. In this review,current immunotherapy approaches to cancer with special focus on dendritic cell (DC)-based cancer vaccines arediscussed. Some of the DC-based vaccines under clinical trials for various cancer types are highlighted. Establishingtumour immunity involves a plethora of immune components and pathways; hence, combining chemotherapy,radiation therapy and various arms of immunotherapy, after analysing the benefits of individual therapeutic agents,might be beneficial to the patient.

    • Author Affiliations

       

      CHAITANYA KUMAR1 SAKSHI KOHLI1 POONAMALLE PARTHASARATHY BAPSY2 ASHOK KUMAR VAID3 MINISH JAIN4 VENKATA SATHYA SURESH ATTILI5 BANDANA SHARAN1

      1. APAC Biotech Pvt Ltd, Gurgaon, India
      2. Department of Oncology, Apollo Hospital, Bengaluru, India
      3. Medanta, Gurgaon, India
      4. Ruby Hall Clinic, Pune, India
      5. Apollo Hospital, Hyderabad, India
    • Dates

       
  • Journal of Biosciences | News

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      Posted on July 25, 2019

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