• Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family

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    • Keywords


      Cell cycle regulation; SET1 family; transcription; WRAD

    • Abstract


      WD repeat containing protein 5 (WDR5), Retinoblastoma Binding Protein 5 (RbBP5), Absent-Small-Homeotic-2-Like protein (ASH2L), and Dumpy-30 (Dpy30) have been reported to be the integral and shared components of all theSET1 family of histone 3 lysine 4 histone methyltransferase (HMT) complexes. Collectively called the WRADcomplex, these proteins are pivotal to the HMT activity of the SET1 complexes. Recent reports highlight the novelnon-canonical functions of WRAD in cellular processes other than its well-studied role in histone methylation andgene expression. In this review, we examine the diversity in emerging transcription-independent functions of WRAD.

    • Author Affiliations



      1. Laboratory of Cell Cycle Regulation, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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