WD repeat containing protein 5 (WDR5), Retinoblastoma Binding Protein 5 (RbBP5), Absent-Small-Homeotic-2-Like protein (ASH2L), and Dumpy-30 (Dpy30) have been reported to be the integral and shared components of all theSET1 family of histone 3 lysine 4 histone methyltransferase (HMT) complexes. Collectively called the WRADcomplex, these proteins are pivotal to the HMT activity of the SET1 complexes. Recent reports highlight the novelnon-canonical functions of WRAD in cellular processes other than its well-studied role in histone methylation andgene expression. In this review, we examine the diversity in emerging transcription-independent functions of WRAD.
Volume 45, 2020
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