• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/042/01/0149-0153

    • Keywords

       

      DNA damage; double-strand break; genomic instability; infertility; MMEJ; NHEJ; pesticides

    • Abstract

       

      Endosulfan is a broad-spectrum organochlorine pesticide, speculated to be detrimental to human health in areas ofactive exposure. However, the molecular insights to its mechanism of action remain poorly understood. In two recentstudies, our group investigated the physiological and molecular aspects of endosulfan action using in vitro, ex vivo andin vivo analyses. The results showed that apart from reducing fertility levels in male animals, Endosulfan inducedDNA damage that triggers compromised DNA damage response leading to undesirable processing of broken DNAends. In this review, pesticide use especially of Endosulfan in the Indian scenario is summarized and the importance ofour findings, especially the rationalized use of pesticides in the future, is emphasized.

    • Author Affiliations

       

      ROBIN SEBASTIAN1 SATHEES C RAGHAVAN1

      1. Department of Biochemistry, Indian Institute of Science, Bengaluru 560 012, India
    • Dates

       
  • Journal of Biosciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2017-2019 Indian Academy of Sciences, Bengaluru.