Heterochromatin and the molecular mechanisms of ‘parent-of-origin’ effects in animals
Twenty five years ago it was proposed that conserved components of constitutive heterochromatin assemble heterochromatinlikecomplexes in euchromatin and this could provide a general mechanism for regulating heritable (cell-to-cell) changesin gene expressibility. As a special case, differences in the assembly of heterochromatin-like complexes on homologouschromosomes might also regulate the parent-of-origin-dependent gene expression observed in placental mammals. Here,the progress made in the intervening period with emphasis on the role of heterochromatin and heterochromatin-likecomplexes in parent-of-origin effects in animals is reviewed.
PRIM B SINGH1 2
Volume 45, 2020
Continuous Article Publishing mode
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