• Heterochromatin and the molecular mechanisms of ‘parent-of-origin’ effects in animals

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    • Keywords


      Epigenetics; genomic imprinting; heterochromatin; HP1; KRAB-ZFP

    • Abstract


      Twenty five years ago it was proposed that conserved components of constitutive heterochromatin assemble heterochromatinlikecomplexes in euchromatin and this could provide a general mechanism for regulating heritable (cell-to-cell) changesin gene expressibility. As a special case, differences in the assembly of heterochromatin-like complexes on homologouschromosomes might also regulate the parent-of-origin-dependent gene expression observed in placental mammals. Here,the progress made in the intervening period with emphasis on the role of heterochromatin and heterochromatin-likecomplexes in parent-of-origin effects in animals is reviewed.

    • Author Affiliations


      PRIM B SINGH1 2

      1. Fächerverbund Anatomie, Institut für Zell- und Neuro-biologie, Charite - Universitätsmedizin, 10117, Berlin, Germany
      2. Department of Natural Sciences and Psychology, Liverpool John Moores University, Life Sciences Building, Byrom Street, Liverpool L3 3AF, UK
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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