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      https://www.ias.ac.in/article/fulltext/jbsc/041/04/0659-0666

    • Keywords

       

      Coronary artery; serotonin reuptake inhibition; sertraline; voltage-dependent K+ channel

    • Abstract

       

      We examined the effects of the selective serotonin reuptake inhibitor (SSRI) sertraline on voltage-dependent K+ (Kv)channels in freshly isolated rabbit coronary arterial smooth muscle cells using the voltage-clamp technique. Sertralinedecreased the Kv channel current in a dose-dependent manner, with an IC50 value of 0.18 μM and a slope value (Hillcoefficient) of 0.61. Although the application of 1 μM sertraline did not affect the steady-state activation curves,sertraline caused a significant, negative shift in the inactivation curves. Pretreatment with another SSRI, paroxetine,had no significant effect on Kv currents and did not alter the inhibitory effects of sertraline on Kv currents. From theseresults, we concluded that sertraline dose-dependently inhibited Kv currents independently of serotonin reuptakeinhibition by shifting inactivation curves to a more negative potential.

    • Author Affiliations

       

      HAN SOL KIM1 HONGLIANG LI1 HYE WON KIM1 SUNG EUN SHIN1 IL-WHAN CHOI2 AMY L FIRTH3 HYOWEON BANG4 YOUNG MIN BAE5 WON SUN PARK1

      1. Department of Physiology, Kangwon National University School of Medicine Chuncheon 200-701, South Korea
      2. Department of Microbiology, Inje University College of Medicine Busan 614-735, South Korea
      3. Department of Pulmonary, Critical Care and Sleep Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
      4. Department of Physiology, College of Medicine, Chung-Ang University Seoul 06974, South Korea
      5. Department of Physiology, Konkuk University School of Medicine, Chungju 380-701 South Korea
    • Dates

       
  • Journal of Biosciences | News

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