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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/041/04/0569-0575

    • Keywords

       

      Ayurveda; bleomycin; reactive oxygen species; Triphala; X-radiation

    • Abstract

       

      Ayurveda is a holistic medical system of traditional medicine, and Triphala is one of the most popular formulations inAyurveda. Triphala is composed of three kinds of herb, Terminalia chebula, Terminalia bellirica, and Emblicaofficinalis. Since Triphala is shown to exhibit a protective activity against ionizing radiation in mice, we investigatedits activity in HeLa cells. We found that Triphala showed the protective effects against X-radiation and bleomycin,both of which generate DNA strand breaks, in HeLa cells. Further, Triphala efficiently eliminated reactive oxygenspecies (ROS) in HeLa cells. Thus, the antioxidant activity of Triphala would likely play a role in its protective actionsagainst X-radiation and bleomycin because both agents damage DNA through the generation of ROS. Theseobservations suggested that the radioprotective activity of Triphala can be, at least partly, studied with the cellscultured in vitro. The simple bioassay system with human cultured cells would facilitate the understanding of themolecular basis for the beneficial effects of Triphala.

    • Author Affiliations

       

      YUKI TAKAUJI1 2 KENSUKE MIKI1 2 JUMA MITA1 MOHAMMAD NAZIR HOSSAIN3 MASATAKE YAMAUCHI4 MITOMU KIOI5 DAI AYUSAWA1 2 MICHIHIKO FUJII1

      1. Graduate School of Nanobioscience, Yokohama City University, Kanagawa 236-0027, Japan
      2. Ichiban Life Corporation, Kanagawa 231-0048, Japan
      3. Department of Biochemistry, Primeasia University, Dhaka 1213, Bangladesh
      4. National Institute of Radiological Sciences, Chiba 263-8555, Japan
      5. Yokohama City University Graduate School of Medicine, Kanagawa 236-0008, Japan
    • Dates

       
  • Journal of Biosciences | News

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