Therapeutic resistance and cancer recurrence mechanisms: Unfolding the story of tumour coming back
MOHAMMAD JAVAD DEHGHAN ESMATABADI BABAK BAKHSHINEJAD FATEMEH MOVAHEDI MOTLAGH SADEGH BABASHAH MAJID SADEGHIZADEH
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Cancer recurrence is believed to be one of the major reasons for the failure of cancer treatment strategies. Thisbiological phenomenon could arise from the incomplete eradication of tumour cells after chemo- and radiotherapy.Recent developments in the design of models reflecting cancer recurrence and in vivo imaging techniques have ledresearchers to gain a deeper and more detailed insight into the mechanisms underlying tumour relapse. Here, weprovide an overview of three important drivers of recurrence including cancer stem cells (CSCs), neosis, and phoenixrising. The survival of cancer stem cells is well recognized as one of the primary causes of therapeutic resistance inmalignant cells. CSCs have a relatively latent metabolism and show resistance to therapeutic agents through a varietyof routes. Neosis has proven to be as an important mechanism behind tumour self-proliferation after treatment whichgives rise to the expansion of tumour cells in the injured site via production of Raju cells. Phoenix rising is a prorecurrencepathway through which apoptotic cancer cells send strong signals to the neighbouring diseased cellsleading to their multiplication. The mechanisms involved in therapeutic resistance and tumour recurrence have not yetbeen fully understood and mostly remain unexplained. Without doubt, an improved understanding of the cellularmachinery contributing to recurrence will pave the way for the development of novel, sophisticated and effective antitumourtherapeutic strategies which can eradicate tumour without the threat of relapse.
MOHAMMAD JAVAD DEHGHAN ESMATABADI1 BABAK BAKHSHINEJAD1 FATEMEH MOVAHEDI MOTLAGH2 SADEGH BABASHAH1 MAJID SADEGHIZADEH1
Volume 48, 2023
Continuous Article Publishing mode
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