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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/040/05/0955-0968

    • Keywords

       

      Autopoiesis; biological organization; criticality; default state; development; emergence; mathematical symmtries

    • Abstract

       

      Lacking an operational theory to explain the organization and behaviour of matter in unicellular and multicellular organisms hinders progress in biology. Such a theory should address life cycles from ontogenesis to death. This theory would complement the theory of evolution that addresses phylogenesis, and would posit the oretical extensions to accepted physical principles and default states in order to grasp the living state of matter and define proper biological observables. Thus, we fanout adopting the default state implicit in Darwins theory, namely, cell proliferation with variation plus motility, and a framing principle, namely, life phenomena manifest themselves as non-identical iterations of morphogenetic processes. From this perspective, organisms become a consequence of the inherent variability generated by proliferation, motility and self-organization. Morphogenesis would then be the result of the default state plus physical constraints, like gravity, and those present in living organisms, like muscular tension.

    • Author Affiliations

       

      Giuseppe Longo1 2 Maël Montévil2 3 Carlos Sonnenschein2 4 Ana M Soto1 2

      1. Centre Cavaillès,Rèpublique des Savoirs, CNRS USR3608, Collège de France et Ecole Normale Supèrieure, Paris, France
      2. Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA
      3. CNRS, UMR8590 IHPST, Paris, France
      4. Centre Cavaillès, École Normale Supérieure, and Institut d'Etudes Avancees de Nantes, Nantes, France
    • Dates

       
  • Journal of Biosciences | News

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