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      https://www.ias.ac.in/article/fulltext/jbsc/040/02/0269-0279

    • Keywords

       

      Colon cancer; CT26 cells; immunity; Lactobacillus

    • Abstract

       

      Colorectal cancer (CRC) is one of the most prevalent forms of cancer that shows a high mortality and increasing incidence. There are numerous successful treatment options for CRC, including surgery, chemotherapy, radiotherapy and immunotherapy; however, their side effects and limitations are considerable. Probiotics may be an effective strategy for preventing and inhibiting tumour growth through stimulation of host innate and adaptive immunity. We investigated and compared potential anti-tumour immune responses induced by two isolated Lactobacillus strains, Lactobacillus plantarum A and Lactobacillus rhamnosus b, by pre-inoculating mice with lactobacilli for 14 days. Subsequently, subcutaneous and orthotopic intestinal tumours were generated in the pre-inoculated mice using CT26 murine adenocarcinoma cells and were assessed for response against the tumour. Our results indicated that oral administration with L. plantarum inhibited CT26 cell growth in BALB/c mice and prolonged the survival time of tumour-bearing mice compared with mice administered L. rhamnosus. L. plantarum produced protective immunity against the challenge with CT26 cells by increasing the effector functions of CD8+ and natural killer (NK) cell infiltration into tumour tissue, up-regulation of IFN-𝛾 (but not IL-4 or IL-17) production, and promotion of Th1-type CD4+ T differentiation. Consequently, our results suggest that L. plantarum can enhance the anti-tumour immune response and delay tumour formation.

    • Author Affiliations

       

      Jingtao Hu1 2 Chunfeng Wang2 Liping Ye2 Wentao Yang2 Haibin Huang2 Fei Meng2 3 Shaohua Shi2 Zhuang Ding1

      1. College of Veterinary Medicine, Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun 130062, China
      2. College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China
      3. Guangxi Veterinary Research Institute, 51 You Ai Road, Nanning, Guangxi 530001, China
    • Dates

       
  • Journal of Biosciences | News

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