Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts
Jiamei Lu Yanting Zhu Wei Feng Yilin Pan Shaojun Li Dong Han Lu Liu Xinming Xie Guizuo Wang Manxiang Li
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Interleukin-13 (IL-13) is associated with the production of collagen in airway remodelling of asthma. Yet, the molecular mechanisms underlying IL-13 induction of collagen remain unclear; the aim of this study is to address this issue. IL-13 dose- and time-dependently-induced collagen I production in primary cultured airway fibroblasts; this was accompanied with the STAT6 phosphorylation, and pre-treatment of cells with JAK inhibitor suppressed IL-13-induced collagen I production. Further study indicated that IL-13 stimulated JAK/STAT6-dependent PDGF production and subsequent ERK1/2 MAPK activation in airway fibroblasts, and the presence of either PDGF receptor blocker or MEK inhibitor partially suppressed IL-13-induced collagen I production. Taken together, our study suggests that activation of JAK/STAT6 signal pathway and subsequent PDGF generation and resultant ERK1/2 MAPK activation mediated IL-13-induced collagen I production in airway fibroblasts.
Jiamei Lu1 Yanting Zhu1 Wei Feng1 Yilin Pan1 Shaojun Li1 Dong Han1 Lu Liu1 Xinming Xie1 Guizuo Wang1 Manxiang Li1
Volume 48, 2023
Continuous Article Publishing mode
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