• Conservation of PHO pathway in ascomycetes and the role of Pho84

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    • Keywords


      Ascomycetes; dual affinity transport system; PHO pathway; Pho84 transceptor; yeast

    • Abstract


      In budding yeast, Saccharomyces cerevisiae, the phosphate signalling and response pathway, known as PHO pathway, monitors phosphate cytoplasmic levels by controlling genes involved in scavenging, uptake and utilization of phosphate. Recent attempts to understand the phosphate starvation response in other ascomycetes have suggested the existence of both common and novel components of the budding yeast PHO pathway in these ascomycetes. In this review, we discuss the components of PHO pathway, their roles in maintaining phosphate homeostasis in yeast and their conservation across ascomycetes. The role of high-affinity transporter, Pho84, in sensing and signalling of phosphate has also been discussed.

    • Author Affiliations


      Parul Tomar1 2 Sinha Sinha1

      1. Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400 005, India
      2. Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108 Freiburg, Germany
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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