• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/039/03/0351-0364

    • Keywords

       

      Co-expression network; fuzzy; network modules; topological property

    • Abstract

       

      Construction of co-expression network and extraction of network modules have been an appealing area of bioinformatics research. This article presents a co-expression network construction and a biologically relevant network module extraction technique based on fuzzy set theoretic approach. The technique is able to handle both positive and negative correlations among genes. The constructed network for some benchmark gene expression datasets have been validated using topological internal and external measures. The effectiveness of network module extraction technique has been established in terms of well-known p-value, Q-value and topological statistics.

    • Author Affiliations

       

      Priyakshi Mahanta1 Hasin Afzal Ahmed1 Dhruba Kumar Bhattacharyya1 Ashish Ghosh2

      1. Department of Computer Science and Engineering, Tezpur University, Napaam 784 028, India
      2. Machine Intelligent Unit, Indian Statistical Institute, Kolkata 700 108, India
    • Dates

       
    • Supplementary Material

       
  • Journal of Biosciences | News

© 2017-2019 Indian Academy of Sciences, Bengaluru.