ABCA1 C69T gene polymorphism and risk of type 2 diabetes mellitus in a Saudi population
Type 2 diabetes mellitus (T2DM) is a disease induced by complex interactions between environmental factors and certain genetic factors. Genetic variants in the Adenosine Binding Cassette Transporter Proteins 1 (ABCA1) have been associated with abnormalities of serum lipid levels of high-density lipoprotein (HDL-C). Decreased serum levels of HDL-C have often been observed in T2DM cases, and this condition has been considered to be involved in the mechanism of insulin resistance (IR). Therefore, we investigated possible association between ABCA1 C69T gene polymorphism and T2DMin a Saudi population. This study was carried out with 380 healthy control subjects and 376 T2DM patients. Genotyping of ABCA1 C69T polymorphism was carried out by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism technique. We observed that the frequency of the T allele of the ABCA1 C69T gene was significantly higher in healthy subjects compared to T2DMpatients (0.28 vs 0.45; 𝑝 < 0.0001; OR (95% CI) = 0.4624 (0.3732–0.5729), and therefore the T allele may be a protective factor against T2DM in the Saudi population.
Khalid K Alharbi1 Imran Ali Khan1 Nasser M Al-Daghri2 Anjana Munshi3 Vandana Sharma3 Abdul Khader Mohammed2 Kaiser A Wani2 Yazeed A Al-Sheikh1 May Salem Al-Nbaheen4 5 Mohammed Ghouse Ahmed Ansari2 Rabbani Syed1
Volume 45, 2020
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