• Stem cell function and maintenance - ends that matter: Role of telomeres and telomerase

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      https://www.ias.ac.in/article/fulltext/jbsc/038/03/0641-0649

    • Keywords

       

      Aging; stem cells; telomerase; telomeres

    • Abstract

       

      Stem cell research holds a promise to treat and prevent age-related degenerative changes in humans. Literature is replete with studies showing that stem cell function declines with aging, especially in highly proliferative tissues/organs. Among others, telomerase and telomere damage is one of the intrinsic physical instigators that drive agerelated degenerative changes. In this review we provide brief overview of telomerase-deficient aging affects in diverse stem cells populations. Furthermore, potential disease phenotypes associated with telomerase dysregulation in a specific stem cell population is also discussed in this review. Additionally, the role of telomerase in stem cell driven cancer is also briefly touched upon.

    • Author Affiliations

       

      Hamid Saeed1 Mehwish Iqtedar2

      1. Department of Endocrinology, School of Medicine, Stanford University, Stanford, CA, USA
      2. Department of Bio-technology & Microbiology, Lahore College for Women University, Lahore, Pakistan
    • Dates

       
  • Journal of Biosciences | News

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      Posted on July 25, 2019

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