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      https://www.ias.ac.in/article/fulltext/jbsc/038/03/0523-0532

    • Keywords

       

      MicroRNA; migration; miR-200a; NSCLC; TSPAN1

    • Abstract

       

      MicroRNA-200a (miR-200a) has been reported to regulate tumour progression in several tumours; however, little is known about its role in non-small cell lung cancer cells (NSCLCs). Here, we found that miR-200a was up-regulated in A549 and SK-MES-1 cells compared with normal lung cells HELF. By a series of gain-of-function and loss-offunction studies, over-expression of miR-200a was indicated to enhance cells migration, and its knock-down inhibited migration of cells in NSCLC cell lines. Furthermore, miR-200a was identified to induce TSPAN1 expression which was related to migration. TSPAN1 was proved to induce migration, and so up-regulation of TSPAN1 by miR-200a may explain why over-expressing miR-200a promotes NSCLC cells migration.

    • Author Affiliations

       

      Yaqing Chen1 2 Wei Peng2 Yixiang Lu2 Jianxin Chen2 York Yuanyuan Zhu2 Tao Xi1

      1. School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China
      2. Biomics Biotechnologies Co. Ltd, Nantong, 226016, China
    • Dates

       
  • Journal of Biosciences | News

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